Magnesium Glycinate
Magnesium Glycinate

Magnesium Glycinate

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"You can trace every sickness, disease and ailment to a mineral deficiency."
- Dr. Linus Pauling, Nobel Prize in Chemistry


Magnesium is an essential macromineral and electrolyte, required for thousands of biochemical processes within the body. It's important for protein synthesis (it activates 3,751 proteins (Piovesan et al, 2012) and thousands of enzyme systems), metabolic health, cardiovascular health, muscle function, nerve cellular communication, preventing cancer, shrinking tumors, and much more.

Magnesium Deficiency

Magnesium deficiency is very common today among humans and animals. It often goes undiagnosed, and fails to be recognized as the root cause of various illnesses. Chronic or severe magnesium deficiency leads to a wide variety of symptoms and diseases.

It has been estimated that 70-90% of Americans today are magnesium deficient. This is in part due to a highly-processed diet, but is also a result of our soils becoming increasingly more depleted, with pH imbalances and without proper mineral replenishment. The produce our ancestors had access to likely had 4 times the amount of nutrients our produce has today. This decrease in minerals has a tremendous impact on our bodies and how well they function.

Horses are No Exception

The combination of depleted soils, stress, pharmaceutical use, GMO grains and by-products, etc, puts our horses at risk for nutrient deficiencies. Even when feeding a high-quality diet, magnesium is a critical nutrient that can be difficult to obtain in optimal amounts. 

Magnesium and Allergies

Low magnesium stores can lead to increased histamine levels and inflammation. Supplementing magnesium glycinate and optimizing the body’s magnesium stores can decrease histamine levels and fight inflammation that commonly occurs with allergies and asthma. It calms the body’s inflammatory response and improves respiratory and lung function. Magnesium also helps relax the smooth muscles that line the airways, opening them up and reducing bronchial spasms.

Magnesium and Cushing's Disease (PPID)

Magnesium works as a prime component of pituitary gland secretions in order to regulate the functioning of other important endocrine glands (adrenal, thyroid, reproductive). Ultimately, proper functioning of the pituitary "master gland" impacts overall hormonal balance, and cortisol (ACTH) and insulin are both hormones. If magnesium is not available, the pituitary gland may not function properly, and the body will likely suffer symptoms of pituitary malfunction.

Magnesium and Equine Metabolic Syndrome (EMS), Insulin Resistance (IR)

Magnesium plays a vital role in all of the body’s metabolic functions. Low serum and intracellular magnesium concentrations are associated with insulin resistance (IR), impaired glucose tolerance, and decreased insulin secretion. Optimizing magnesium stores can help to prevent the development of IR and help manage IR.

"Intracellular magnesium deficiency may affect the development of insulin resistance and alter the glucose entry into the cell. Magnesium is required for both proper glucose utilization and insulin signaling. Metabolic alterations in cellular magnesium, which may play a role of a second messenger for insulin action, contribute to insulin resistance."

-PubMed Article

Magnesium and Polysaccharide Storage Myopathy (PSSM/EPSM)

Supplementing magnesium glycinate can support horses with Polysaccharide Storage Myopathy, potentially minimizing symptoms. One can speculate whether a magnesium deficiency is the root, or part of the root cause of diagnosis' such as PSSM/EPSM...

"Exercise intolerance, fatigue, muscle tremors, tying up, and behavioral issues from naughtiness, hyperactivity, nervousness, and excitability - the symptoms of Magnesium deficiency - are in fact very similar to the symptoms of PSSM." 


Magnesium and Hyperkalemic Periodic Paralysis (HYPP)

Supplementing magnesium glycinate can support horses with Hyperkalemic Periodic Paralysis as magnesium helps to balance potassium levels in the muscle. One can speculate whether a magnesium deficiency is the root, or part of the root cause of diagnosis' such as HYPP...

"“Magnesium and potassium have a close relationship. Magnesium is necessary for the function of the sodium/potassium pump. If a magnesium deficiency occurs, then pumping sodium out of the cell and pumping potassium into the cell may be impaired. ...magnesium intake can normalize both magnesium and potassium levels in the muscle."


Magnesium and Cancer

 “A complex relationship links magnesium and cancer. Magnesium is a serious cancer medicine because it stabilizes ATP and allows for DNA and RNA transcriptions and repairs. Magnesium deficiency has been shown to be carcinogenic, and in the case of solid tumors, a high level of supplemented magnesium inhibits carcinogenesis. Magnesium repletion has been shown to produce rapid disappearances of the periosteal tumors.“

-Dr. Mark Sircus

Magnesium Glycinate 

There are several forms of supplemental magnesium, however, Magnesium glycinate is commonly recognized as one of the safest, most bioavailable forms; trusted for its high absorption rate and usually being very well-tolerated. Magnesium glycinate is the combination of magnesium salt bound with amino acid glycine. Glycine has added benefits due to its calming properties.


Common Signs of Magnesium Deficiency

  • Overreactive to stimuli, sound or touch
  • Muscle pain, spasms, cramps, twitches, tremors, flinching or seizures
  • Poor cognitive processing
  • Mood and Behavioral problems
    • Anxiety
    • Aggression
    • Spooking
    • Inconsistent behavior
    • Bucking / rearing midway into training session
  • Physical tension / stiffness
  • Chronic pain
  • Headaches
  • Numbness and tingling
  • Irregular, racing or pounding heartbeat
  • Irregular calcium levels
  • Tying up
  • Loss of appetite
  • Teeth grinding
  • Difficulty swallowing
  • Failure to thrive (mostly in foals)
  • Fatigue
  • Allergies
  • Navicular (acidosis)
  • Insulin Resistance (IR) 
  • Diabetes
  • Stringhalt & more


Benefits of Supplemental Magnesium:

  • Essential mineral & electrolyte
    • Required for 300+ metabolic processes in the body
  • Supports proper muscle & nerve function
    • Minimizes muscle cramps & nerve pain
    • Can reduce stiffness
    • Reduces headaches
  • Supports a balanced mood
    • Reduces anxiety
  • Supports balanced blood sugar levels
    • Helps regulate glucose & insulin levels (Low levels of magnesium increase the risk of developing insulin resistance)
    • Helps prevent laminitis
  • Supports horses with Cushing's Disease
    • Supports pituitary gland function
    • Supports balanced hormones (including cortisol (ACTH))
  • Supports a normal inflammatory response
  • Supportive for EPSM / PSSM
  • Supports healthy energy levels
  • Supports protein synthesis / helps muscle recovery
  • Minimizes menstrual symptoms / PMS
    • Supports Navicular
      • Supports bone health
      • Optimizes bone mineral density
    • Minimizes allergies
      • Decreases histamine levels & inflammation
    • Helps optimize healthy sleep cycles
    • Supports neurological function / brain health
    • Reduces risk of seizures
    • Can improve asthma & breathing disorders
      • Relaxes bronchial muscles
      • Regulates breathing
    • Boosts collagen production
    • Enhances mineral absorption
      • Magnesium helps absorb & assimilate many other essential minerals
      • Regulates calcium levels
    • Supports bladder function
    • Improves digestion & more


    Ingredients: 100% Magnesium glycinate.

    Serving Size:  2 scoops daily, per every 1,000 lbs of body weight (2 scoops = 1,750 mg of available magnesium). Divide between AM & PM offerings & dilute in meals.

    Introduce gradually; some horses may only require a half-dose. If your horse develops loose stools, you can pause / give them a break and reintroduce slowly at a lower dose to find his or her best tolerated dosage.

    Storage: Please store in a cool, dry place.
    “There is no substitute for magnesium in human physiology; nothing comes even close to it in terms of its effect on overall cell physiology. Without sufficient magnesium, the body accumulates toxins and acid residues, degenerates rapidly, and ages prematurely. It goes against a gale wind of medical science to ignore magnesium in the treatment of any chronic or acute disorder, especially cancer.“
    —Dr. Sircus
    Bulk Pricing:
          35-week supply (2,381 g / 5.25 lbs) = $77.00 (30% discount)
    Related: Excellent sources of naturally occurring, highly bioavailable magnesium are pumpkin seeds and hemp hearts, so if you're feeding our Grace's Abundance blend, then your horse is already getting a fair amount of magnesium naturally - our favorite way! In this case, a healthy horse may only need a half dose of Magnesium Glycinate, but a horse with any condition should be offered a full dose in conjunction.
    Related: Having too much magnesium in the body is rare, as excess is typically readily excreted in urine. With this said, please do not exceed the recommended serving size.

    Warning: Feed with caution in horses with known kidney issues. Seek veterinary counsel first.